Cajun Chicken Alfredo Fettuccine

Featured in: Comfort Food

This dish blends tender chicken seasoned with bold Cajun spices with creamy Velveeta cheese sauce and perfectly cooked fettuccine pasta. Garlic and butter create a fragrant base while Parmesan adds depth. Adjust the cayenne for extra heat or add vegetables like peppers or mushrooms to enrich flavors. Ideal for a quick, comforting meal with Southern-inspired richness and a smooth, cheesy finish.

Updated on Sun, 23 Nov 2025 14:09:00 GMT
Tender Cajun chicken atop creamy, cheesy Cajun Chicken Alfredo Fettuccine Pasta, garnished with fresh parsley. Save
Tender Cajun chicken atop creamy, cheesy Cajun Chicken Alfredo Fettuccine Pasta, garnished with fresh parsley. | bakozy.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This dish quickly became a family favorite after I served it on a busy weeknight. Everyone loved the cheesy, tangy sauce and the perfect kick from the Cajun seasoning.

Ingredients

  • Chicken: 2 large boneless, skinless chicken breasts, 1 ½ tablespoons Cajun seasoning, 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter, 2 cloves garlic minced, 1 cup (240 ml) heavy cream, 8 oz (225 g) Velveeta cheese cubed, ½ cup (50 g) grated Parmesan cheese, ½ teaspoon black pepper, ¼ teaspoon cayenne pepper (optional for extra heat), Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped, Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet heat olive oil over medium-high heat. Add chicken and cook 5 6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
A steaming bowl of comforting Cajun Chicken Alfredo Fettuccine Pasta, rich Velveeta sauce and spices. Save
A steaming bowl of comforting Cajun Chicken Alfredo Fettuccine Pasta, rich Velveeta sauce and spices. | bakozy.com

My kids always request this pasta on weekends and enjoy helping with the slicing and garnishing steps that bring the dish together.

Required Tools

Large pot, large skillet, knife and cutting board, tongs or pasta fork, measuring cups and spoons

Allergen Information

This recipe contains milk/dairy products such as Velveeta, Parmesan, cream, and butter. It also contains wheat and chicken. Those with allergies should check ingredient labels carefully.

Nutritional Information

Per serving: 670 calories, 32 g total fat, 57 g carbohydrates, 41 g protein

Delicious, homemade Cajun Chicken Alfredo Fettuccine Pasta, a flavorful pasta dish perfect for dinner tonight. Save
Delicious, homemade Cajun Chicken Alfredo Fettuccine Pasta, a flavorful pasta dish perfect for dinner tonight. | bakozy.com

This Cajun Chicken Alfredo is the perfect blend of creamy, spicy, and savory to satisfy any pasta craving.

Recipe FAQ

How do I ensure the chicken stays tender?

Pat the chicken dry before seasoning and cook over medium-high heat just until golden and cooked through to retain moisture.

Can I substitute Velveeta cheese?

For a similar creamy texture, processed cheeses or a blend of cream cheese and mild cheddar can work, though flavor may vary.

How to adjust the spice level?

Modify the amount of Cajun seasoning and cayenne pepper according to your preference for heat intensity.

What pasta is recommended?

Fettuccine pasta works best for coating with the creamy sauce and providing a balanced bite with the chicken.

Can I make this dish ahead of time?

Cook the components separately and store them chilled. Combine and warm gently before serving to maintain texture and flavor.

What garnishes enhance the dish?

Fresh parsley and extra grated Parmesan add brightness and depth, complementing the rich sauce and spices.

Cajun Chicken Alfredo Fettuccine

Comforting Cajun-seasoned chicken with rich Velveeta sauce over tender fettuccine pasta.

Prep duration
15 min
Heat time
25 min
Complete duration
40 min
Created by Natalie Harris


Complexity Easy

Heritage American (Cajun-inspired)

Output 4 Portions

Nutrition specifications None specified

Components

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 oz Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Directions

Phase 01

Cook fettuccine: Bring a large pot of salted water to a boil. Cook fettuccine according to package directions until al dente. Drain, reserving ½ cup of pasta water, and set pasta aside.

Phase 02

Prepare chicken: Pat chicken breasts dry and evenly coat both sides with Cajun seasoning.

Phase 03

Sear chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5 to 6 minutes per side until golden brown and internal temperature reaches 165°F. Remove from heat and let rest for 5 minutes before slicing thinly.

Phase 04

Sauté garlic: Reduce skillet heat to medium. Add butter and minced garlic, sautéing for 1 minute until fragrant.

Phase 05

Prepare cheese sauce: Stir in heavy cream and bring to a gentle simmer. Add Velveeta cheese cubes, stirring constantly until melted and smooth.

Phase 06

Season sauce: Incorporate grated Parmesan, black pepper, and cayenne pepper if using. Stir until fully combined and creamy. If sauce is too thick, gradually add reserved pasta water until desired consistency is reached.

Phase 07

Combine pasta and sauce: Toss cooked fettuccine in the cheese sauce until evenly coated.

Phase 08

Plate and garnish: Divide pasta among plates, top with sliced Cajun chicken. Garnish with chopped parsley and additional Parmesan cheese if desired.

Tools needed

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy details

Review each component for potential allergens and if uncertain, we recommend consulting with a healthcare provider.
  • Contains milk/dairy products (Velveeta, Parmesan, cream, butter).
  • Contains wheat (fettuccine).
  • Contains poultry (chicken).

Nutrient breakdown (per portion)

These values are estimates only and shouldn't replace professional medical guidance.
  • Energy: 670
  • Fats: 32 g
  • Carbohydrates: 57 g
  • Proteins: 41 g